Interpretation of FOREL clusters
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چکیده
Supplementary Figure 1. Alternative analysis of cluster centroid juxtaposition with MEGA2 software. A: UPGMA tree based on Euclidean distance between cluster centroids; B: Neighbor-joining tree based on inter-centroid distance matrix; C: UPGMA tree based on average Euclidean distance between cluster elements; D: Neighbor-joining tree based on average Euclidean distance between cluster elements. All alternative analyses of relative positions of cluster centroids are consistent with the results of 2-step dimensionality reduction visualization presented in the paper. Clusters 1 and 8 are singletons represented normal samples, closely associated with each other and/or cluster 3. Cluster 3 is a dense group of very similar “most metabolically fit” samples. All other clusters contain a mixture of normal, impaired or diabetic samples situated approximately along one line stretching between cluster 3 and cluster 7 (least metabolically fit cluster). c lu3 c lu2 c lu4 c lu5 c lu6 c lu7 c lu8 c lu1
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